pentobarbital will lower the level or impact of larotrectinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the level or effect of clarithromycin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.pentobarbital will reduce the level or effect of nelfinavir by influencing hep